反应详情

温度

-78 °C

BuLi (1.6M in hexanes, 27.0 mL, 43.1 mmol) was added to a sol. of (4-bromophenoxy)-tert-butyldimethylsilane (12.4 g, 43.1 mmol) in THF (300 mL) at −78° C. The mixture was stirred for 30 min at −78° C., and ZnCl2 (1M in THF, 52.4 mL, 52.4 mmol) was added. The mixture was allowed to warm to rt, and a sol. of 4-trifluoromethanesulfonyloxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (WO 2004/002957; 12.0 g, 30.8 mmol) in THF (20 mL) and Pd(PPh3)4 (1.00 g, 0.863 mmol) were added. The mixture was stirred at rt overnight, and aq. sat. NH4Cl was added. The mixture was extracted with EtOAc. The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the crude by FC (EtOAc/heptane 1:9→1:1) yielded the title compound (13.3 g, 96%). LC-MS: tR=1.20 min; ES+: 448.35.

1. temperatureto warm to rt
2. stirringThe mixture was stirred at rt overnight
3. extractionThe mixture was extracted with EtOAc
4. dry with materialextracts were dried over MgSO4
5. filtrationfiltered
6. customthe solvents were removed under reduced pressure
7. customPurification of the crude by FC (EtOAc/heptane 1:9→1:1)