反应详情

A mixture of (R)-3-(2-nitrophenylamino)piperidine-1-carboxylic acid tertbutyl ester (2.48 g, 7.72 mmol) and 10% Pd/C (250 mg) in EtOAc (50 mL) was degassed with a stream of nitrogen and stirred at RT under a hydrogen atmosphere for 20 h. The suspension was then filtered through a PTFE frit and the filtrate was concentrated in vacuo affording (R)-3-(2-Aminophenylamino)piperidine-1-carboxylic acid tertbutyl ester as a clear glass (2.25 g, quantitative). LCMS: RT 2.64 min [M+H-Boc]+ 192.1.

1. customwas degassed with a stream of nitrogen
2. filtrationThe suspension was then filtered through a PTFE frit
3. concentrationthe filtrate was concentrated in vacuo