反应详情

温度

80 °C

A mixture of compound D7 (4.31 g, 8 mmol) in MeOH (50 mL) and aq. 1M NaOH (79 mL) was stirred at 80° C. for 8 h. The mixture was allowed to cool to rt, and aq. 2M HCl (50 mL) was added. The mixture was extracted with EtOAc. The combined org. extracts were washed with brine, dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (4.18 g, quantitative yield). LC-MS: tR=1.12 min, ES+: 524.41.

1. temperatureto cool to rt
2. extractionThe mixture was extracted with EtOAc
3. washextracts were washed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customthe solvents were removed under reduced pressure
7. customDrying the residue under high vacuum