Methanesulfonic Acid → HCID 86630056, compound

HRID 2428286Notes

Reaction equation

HRID 2428286 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][NH:5][C:6](=[O:23])[C:7]([OH:22])([CH3:21])[CH2:8][CH2:9][C:10]1[C:15](=[O:16])[C:14]([CH3:17])=[C:13]([CH3:18])[C:12](=[O:19])[C:11]=1[CH3:20].[CH3:25][S:26]([OH:29])(=[O:28])=[O:27]>C(Cl)Cl>[S:26]([OH:29])(=[O:28])(=[O:27])[CH3:25].[CH3:24][N:2]([CH3:1])[CH2:3][CH2:4][NH:5][C:6](=[O:23])[C:7]([OH:22])([CH3:21])[CH2:8][CH2:9][C:10]1[C:15](=[O:16])[C:14]([CH3:17])=[C:13]([CH3:18])[C:12](=[O:19])[C:11]=1[CH3:20]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 42599869HCID 42599869, compound

Product 1

HCID 86630056HCID 86630056, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(2-(dimethylamino)ethyl)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide (25 mg) was dissolved into 1 mL CH2Cl2 and 5.2 μL neat methanesulfonic acid added to the stirred yellow solution. The solution was concentrated, dissolved into CH2Cl2 and triturated from Et2O giving 20 mg of N-(2-(dimethylamino)ethyl)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide mesylate as a yellow hydroscopic solid.

Workup

  1. additionadded to the stirred yellow solution
  2. concentrationThe solution was concentrated
  3. dissolutiondissolved into CH2Cl2
  4. customtriturated from Et2O giving 20 mg of N-(2-(dimethylamino)ethyl)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide mesylate as a yellow hydroscopic solid

Sources & evidence

ORD record
ord-0ba13e40e6ab4628a543d7ac7faf6fdf
Source dataset
uspto-grants-2011_06
Patent number
US07968746B2

Reaction notes

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