反应详情

Tetrabutylammonium borohydride (nBu4NBH4) (800 mg, 3.10 mmol) was added at RT to a solution of 3-o-tolylbenzo[b]thiophene-2-carbaldehyde (2.07 mmol) in THF (10 mL) and IMS (1 mL) and the mixture was stirred at RT for 1 h. The reaction mixture was then quenched by addition of MeOH and volatiles were removed under reduced pressure. The resulting residues was purified by column chromatography (Si—PCC, gradient 0-30% EtOAc in cyclohexane) affording the title compound as an oil (432 mg, 82% over 2 steps). LCMS: RT 3.74 min [M-OH]+ 237.1.

1. customThe reaction mixture was then quenched by addition of MeOH and volatiles
2. customwere removed under reduced pressure
3. customThe resulting residues was purified by column chromatography (Si—PCC, gradient 0-30% EtOAc in cyclohexane)