反应详情

A mixture of (5-fluoro-2-nitrophenyl)pyridin-2-yl-amine (255 mg, 1.09 mmol) in EtOAc (20 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (28 mg) and was stirred at RT under a hydrogen atmosphere for 18 h. The suspension was filtered through a phase separator and the filtrate concentrated in vacuo to afford the title compound as a black solid (241 mg, quantitative). 1H NMR (CDCl3, 400 MHz): δ 8.20-8.16 (1H, m), 7.51-7.44 (1H, m), 7.12-7.07 (1H, m), 6.78-6.72 (3H, m), 6.55 (1H, dt, J=8.39, 0.93 Hz), 6.22 (1H, s), 3.63 (2H, s).

1. customwas degassed with a stream of nitrogen
2. additionto addition of 10% Pd/C (28 mg)
3. filtrationThe suspension was filtered through a phase separator
4. concentrationthe filtrate concentrated in vacuo