Trifluoroacetic acid → HCID 178496642, compound

HRID 243093Notes

Reaction equation

HRID 243093 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:10]1[N:14]([C@H:15]2[CH2:18][C@@H:17]([O:19][CH3:20])[CH2:16]2)[C:13]2[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:12]=2[N:11]=1)[CH3:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:25][C:22]1[CH:23]=[CH:24][C:12]2[N:11]=[C:10]([C@@H:8]([NH2:7])[CH3:9])[N:14]([C@H:15]3[CH2:18][C@@H:17]([O:19][CH3:20])[CH2:16]3)[C:13]=2[CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178496640HCID 178496640, compound

Product 1

HCID 178496642HCID 178496642, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of {(S)-1-[6-fluoro-1-(cis-3-methoxycyclobutyl)1Hbenzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester (0.22 g, 0.61 mmol) in DCM (5 mL) was added TFA (3 mL) and the mixture was stirred at RT for 1.5 h. The volatiles were removed in vacuo and the resulting residue loaded onto an Isolute® SCX-2 cartridge. The cartridge was washed with MeOH followed by 2M NH3/MeOH. The basic fractions were combined and concentrated in vacuo. The crude material was used in the following step without further purification. Yellow oil (quantitative). LCMS (Method B): RT 1.72 min [M+H]+ 263.90.

Workup

  1. customThe volatiles were removed in vacuo
  2. washThe cartridge was washed with MeOH
  3. concentrationconcentrated in vacuo
  4. customThe crude material was used in the following step without further purification
  5. customRT 1.72 min [M+H]+ 263.90

Sources & evidence

ORD record
ord-3a14b20c23ed47d7980e5b63d0b38d16
Source dataset
uspto-grants-2014_02
Patent number
US08653089B2

Reaction notes

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