2-Cyclopropylamino-6-fluoro-3-nitrobenzoic acid methyl ester → 3-Amino-2-cyclopropylamino-6-fluorobenzoic acid methyl ester

Participants

Reaction Steps

A mixture of 2-cyclopropylamino-6-fluoro-3-nitrobenzoic acid methyl ester (865 mg, 3.40 mmol) in EtOAc (25 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (116 mg) and was stirred at RT under a hydrogen atmosphere for 20 h. The suspension was filtered and the filtrate was concentrated in vacuo to afford the title compound as a dark yellow oil (756 mg, 99%). LCMS (Method C): RT 2.29 min [M+H]+ 225.18.

Provenance & Evidence