反应详情

A mixture of 2-cyclopropylamino-6-fluoro-3-nitrobenzoic acid methyl ester (865 mg, 3.40 mmol) in EtOAc (25 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (116 mg) and was stirred at RT under a hydrogen atmosphere for 20 h. The suspension was filtered and the filtrate was concentrated in vacuo to afford the title compound as a dark yellow oil (756 mg, 99%). LCMS (Method C): RT 2.29 min [M+H]+ 225.18.

1. customwas degassed with a stream of nitrogen
2. additionto addition of 10% Pd/C (116 mg)
3. filtrationThe suspension was filtered
4. concentrationthe filtrate was concentrated in vacuo