反应详情

A mixture of (5-fluoro-2-nitro-phenyl)-(3-fluoropyridin-2-yl)amine (93 mg, 0.370 mmol) in EtOAc (10 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (10 mg) and was stirred at RT under a hydrogen atmosphere for 3 h. The mixture was then filtered through a phase separator and the filtrate was concentrated in vacuo to afford the title compound as a brown solid (81 mg, 99%). LCMS (Method C): RT 1.70 min [M+H]+ 222.18.

1. customwas degassed with a stream of nitrogen
2. additionto addition of 10% Pd/C (10 mg)
3. filtrationThe mixture was then filtered through a phase separator
4. concentrationthe filtrate was concentrated in vacuo