HCID 68158215, compound → HCID 68157152, compound

HRID 243145Notes

Reaction equation

HRID 243145 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-])=O)=[C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH3:14])[N:10]=2)[CH:7]=1>CCOC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH3:14])[N:10]=2)[C:5]([NH2:15])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 68158215HCID 68158215, compound

Product 1

HCID 68157152HCID 68157152, compoundYield 104.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of (5-fluoro-2-nitro-phenyl)-(1-methyl-1H-pyrazol-3-yl)amine (386 mg, 1.63 mmol) in EtOAc (10 mL) was degassed with a stream of nitrogen prior to the addition of 10% Pd/C (50 mg) and was stirred at RT under a hydrogen atmosphere for 24 h. The mixture was filtered and the filtrate was concentrated in vacuo to afford the title compound as a grey oil (350 mg, quant.). LCMS (Method C): RT 1.63 min [M+H]+ 207.17

Workup

  1. customwas degassed with a stream of nitrogen
  2. additionto the addition of 10% Pd/C (50 mg)
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-27982ddcb77f49f0891fc20010c323a4
Source dataset
uspto-grants-2014_02
Patent number
US08653089B2

Reaction notes

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