HCID 68157451, compound → HCID 68157931, compound

HRID 243153Notes

Reaction equation

HRID 243153 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-])=O)=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][N:10]=2)[CH:7]=1>[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][N:10]=2)[C:5]([NH2:15])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 68157451HCID 68157451, compound

Product 1

HCID 68157931HCID 68157931, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

(5-Fluoro-2-nitrophenyl)pyrimidin-4-ylamine (0.31 g, 1.32 mmol) in IMS was hydrogenated at RT and pressure for 3.5 h using Pd—C (30 mg) as a catalyst. The catalyst was removed by filtration through Celite. The filtrate was concentrated in vacuo to give the title compound as an orange solid, (0.249 g, 92%). LCMS (Method J): RT=0.56 min, [M+H]+=205.16

Workup

  1. customwas hydrogenated at RT
  2. customThe catalyst was removed by filtration through Celite
  3. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-8a7dc65922c549dfbe43f5722f9c2db3
Source dataset
uspto-grants-2014_02
Patent number
US08653089B2

Reaction notes

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