反应详情

To a solution of 8-fluoro-5-nitro-3,4-dihydro-2H-benzo[1,4]oxazine (290 mg, 1.463 mmol) in EtOAc (15 mL) was added a slurry of 10% Pd/C (50 mg) in IMS (2 mL) and the reaction mixture was stirred at RT under a hydrogen atmosphere for 18 h. The suspension was then filtered through a pad of Celite® and the filtrate was concentrated in vacuo affording the title compound as purple oil (243 mg, 99%).

1. filtrationThe suspension was then filtered through a pad of Celite®
2. concentrationthe filtrate was concentrated in vacuo