Potassium Hydroxide → 4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

HRID 24328Notes

Reaction equation

HRID 24328 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:7]([C:12]([O:14]CC)=[O:13])=[C:8]([CH3:11])[NH:9][CH:10]=1)([OH:3])=[O:2].[OH-].[K+]>C(O)C>[C:1]([CH2:4][CH2:5][C:6]1[C:7]([C:12]([OH:14])=[O:13])=[C:8]([CH3:11])[NH:9][CH:10]=1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 217287442-Methyl-3-carbethoxy-4-(3-propionic acid)pyrrole

Product 1

HCID 225710444-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acidYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(2-Carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole (Bulter, A. R., and George, S. D. (1993) Tetrahedron 49: 7017-7026) was hydrolyzed using potassium hydroxide (KOH) in ethanol (EtOH) to give 4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid (64%).

Sources & evidence

ORD record
ord-0e408daf6e994476bc66956e12dee526
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Reaction notes

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