反应详情

A mixture of 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1.15 g, 4.1 mmol), 1-(1-phenyl-1H-benzo[d]imidazol-2-yl)ethanamine from Example 4 (1.0 g, 4.1 mol) and K2CO3 (0.6 g, 4.3 mmol) in DMSO (20 mL) was stirred at room temperature overnight. Then the mixture was added H2O (50 mL) and extracted with CH2Cl2 (20 mL×3). The combined organic layers were concentrated in vacuo to give 4-chloro-5-iodo-7-(1-phenyl-1H-benzoimidazol-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine (1.7 g, yield 85%) as brown solid.

1. extractionextracted with CH2Cl2 (20 mL×3)
2. concentrationThe combined organic layers were concentrated in vacuo