反应详情

A solution of 4-chloro-5-iodo-7-(1-phenyl-1H-benzoimidazol-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine (1.0 g, 2 mmol) in NH4OH (5 mL) and MeOH (10 mL) was stirred at 90° C. in a sealed tube overnight. Then the mixture was filtered. The precipitate was purified by P-TLC to give 140 (0.4 g, yield 42%) as a white solid. LCMS (ESI), M+H+=465.04 1HNMR (400 MHz, DMSO) δ 5.518 (s, 2H), 6.574 (s, 2H), 7.128 (s, 2H), 7.210-7.232 (m, 2H), 7.343 (s, 1H), 7.521-7.622 (m, 6H), 7.968 (s, 1H)

1. filtrationThen the mixture was filtered
2. customThe precipitate was purified by P-TLC