反应详情

A mixture of 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (1.0 g, 5.9 mmol), 2-(chloromethyl)-1-phenyl-1H-benzo[d]imidazole (1.4 g, 5.9 mmol) and K2CO3 (0.86 g, 6.2 mmol) in DMSO (20 mL) was stirred at room temperature overnight. Then the mixture was added H2O (50 mL) and extracted with CH2Cl2 (20 mL×3). The combined organic layers were concentrated in vacuo to give 4-chloro-1-(1-phenyl-1H-benzoimidazol-2-ylmethyl)-1H-Pyrazolo[3,4-d]pyrimidin-6-ylamine (1.5 g, yield 68%) as orange solid.

1. extractionextracted with CH2Cl2 (20 mL×3)
2. concentrationThe combined organic layers were concentrated in vacuo