Phosphorus oxychloride → HCID 59442834, compound

HRID 243559Notes

Reaction equation

HRID 243559 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([CH3:16])=[CH:11][C:12](=O)[NH:13][N:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:12]1[N:13]=[N:14][C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)=[C:10]([CH3:16])[CH:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 59442803HCID 59442803, compound

Product 1

HCID 59442834HCID 59442834, compound

Conditions

Temperature
100 °C

Procedure

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one (500 mg) is added stepwise to phosphoryl trichloride (1.8 ml). The reaction mixture is heated to 100° C. for 1 hour, then cooled to room temperature and poured onto ice water. The formed precipitate is separated, washed with water and dried to give 3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine (509 mg).

Workup

  1. temperaturecooled to room temperature
  2. additionpoured onto ice water
  3. customThe formed precipitate is separated
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-51cdd7dcfb614e89ba023b8b5a46f1d0
Source dataset
uspto-grants-2014_02
Patent number
US08653262B2

Reaction notes

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