反应详情

温度

100 °C

6-(3,4-dichlorophenyl)-5-methylpyridazin-3(2H)-one (500 mg) is added stepwise to phosphoryl trichloride (1.8 ml). The reaction mixture is heated to 100° C. for 1 hour, then cooled to room temperature and poured onto ice water. The formed precipitate is separated, washed with water and dried to give 3-chloro-6-(3,4-dichlorophenyl)-5-methylpyridazine (509 mg).

1. temperaturecooled to room temperature
2. additionpoured onto ice water
3. customThe formed precipitate is separated
4. washwashed with water
5. customdried