HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-[3-(4-Morpholinyl)propyl]-4-piperidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 3913788 | HCID 3913788 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[3-(4-Morpholinyl)propyl]-4-piperidinecarboxamide | HCID 16769263 | 93.8% |
Reaction Steps
Trifluoroacetic acid (4.4 ml) is added to a solution of tert-butyl 4-(3-morpholinopropylcarbamoyl)piperidine-1-carboxylate (2.3 g) in CH2Cl2 (30 ml), and the mixture is stirred over night. The solvent is removed under reduced pressure to give crude N-(3-morpholinopropyl)piperidine-4-carboxamide (1.55 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653262B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-24bdcfb515114e009b0098ff2fc9d6a3 |
| Source note | uspto-grants-2014_02 |