Trifluoroacetic acid → N-[3-(4-Morpholinyl)propyl]-4-piperidinecarboxamide

HRID 243560Notes

Reaction equation

HRID 243560 reaction equation
FC(F)(F)C(O)=O.[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]([CH:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]2)=[O:19])[CH2:10][CH2:9]1>C(Cl)Cl>[O:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]([CH:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)=[O:19])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 3913788HCID 3913788, compound

Product 1

HCID 16769263N-[3-(4-Morpholinyl)propyl]-4-piperidinecarboxamideYield 93.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (4.4 ml) is added to a solution of tert-butyl 4-(3-morpholinopropylcarbamoyl)piperidine-1-carboxylate (2.3 g) in CH2Cl2 (30 ml), and the mixture is stirred over night. The solvent is removed under reduced pressure to give crude N-(3-morpholinopropyl)piperidine-4-carboxamide (1.55 g).

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-24bdcfb515114e009b0098ff2fc9d6a3
Source dataset
uspto-grants-2014_02
Patent number
US08653262B2

Reaction notes

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