HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 243562Generated: November 3, 2026
2-(4-(4-benzylpiperazin-1-yl)cyclohexyl)-N,N-dimethylethanamine → N,N-dimethyl-2-(4-(piperazin-1-yl)cyclohexyl)ethanamine
https://huagongshe.com/reaction/243562
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(4-(4-benzylpiperazin-1-yl)cyclohexyl)-N,N-dimethylethanamine | HCID 59442789 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N,N-dimethyl-2-(4-(piperazin-1-yl)cyclohexyl)ethanamine | HCID 59442815 | 85.9% |
Reaction Steps
2-(4-(4-benzylpiperazin-1-yl)cyclohexyl)-N,N-dimethylethanamine (660 mg) is dissolved in ethanol (20 ml). Palladium on carbon (100 mg) is added and the mixture is stirred for 16 hours at 50° C. under an atmosphere of hydrogen (50 psi). The catalyst is removed by filtration and the filtrate concentrated under reduced pressure to give N,N-dimethyl-2-(4-(piperazin-1-yl)cyclohexyl)ethanamine (412 mg). m/z(+) 240 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653262B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-8c65695575ec4d6391e0bc8001de19b8 |
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| Source note | uspto-grants-2014_02 |
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