Dichloromethane → HCID 66891072, compound

HRID 243606Notes

Reaction equation

HRID 243606 reaction equation
[CH3:1][C@@H:2]([CH2:45][CH3:46])[C@H:3]([N:11]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][O:24][C:25]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:18]=2)[C:12]1=[O:44])[C:4]([O:6]C(C)(C)C)=[O:5].ClCCl>FC(F)(F)C(O)=O>[CH3:1][C@@H:2]([CH2:45][CH3:46])[C@H:3]([N:11]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][O:24][C:25]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[N:18]=2)[C:12]1=[O:44])[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 86598724HCID 86598724, compound

Product 1

HCID 66891072HCID 66891072, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product of Example 286B (0.35 g) in trifluoroacetic acid:dichloromethane (3 mL, 2:1) was stirred at 25° C. for 2 hrs. The solvents were evaporated and the residue was directly used for the next step.

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-bbbaa15a924145718c473586ea160e87
Source dataset
uspto-grants-2014_02
Patent number
US08653141B2

Reaction notes

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