Dichloromethane → HCID 55279814, compound

HRID 243616Notes

Reaction equation

HRID 243616 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10](C)=[CH:9][C:8]=1[OH:14].Cl[CH2:16]Cl>>[Cl:6][C:7]1[CH:12]=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:10]=[C:9]([CH3:16])[C:8]=1[OH:14]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 120082-Chloro-5-methylphenolHCID 24638Chlorosulfonic acid

Product 1

HCID 55279814HCID 55279814, compoundYield 11.3%

Procedure

To a solution of chlorosulfonic acid (1.22 g, 10.5 mmol) dissolved in 10 mL of dichloromethane was added 2-chloro-5-methylphenol (1.0 g, 7.0 mmol) dropwise. After 10 minutes, the reaction was quenched by pouring it into ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 190 mg (11.3%) of the title compound.

Workup

  1. customthe reaction was quenched
  2. additionby pouring it into ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-456926d4c56f43b5a606c9c0b1779f00
Source dataset
uspto-grants-2014_02
Patent number
US08653141B2

Reaction notes

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