反应详情

The compound V (6.0 g, 0.03 mol) produced as described above and potassium carbonate (5 g) were added to 20 ml of water and 40 ml of dichloromethane, and stirred for 30 minutes. The aqueous layer was removed. The organic layer was cooled to the temperature of 0° C., and acetyl chloride (7.8 g, 0.1 mol) was added dropwise. A reaction was allowed to proceed at room temperature for 1 hour. 100 ml water was then added, and the reaction solution was extracted with dichloromethane (50 ml*3). The organic phases were combined, dried with anhydrous magnesium sulfate, and filtered to remove the drying agent. The filtrate was concentrated under reduced pressure, to give a solid. The solid was recrystallized in a 2:1 toluene/n-hexane mixture, to produce 4.8 g of agomelatine. The yield was 78.5%. The melting point was 107-108° C. (in Literature [2], 109° C.).

1. customThe aqueous layer was removed
2. additionwas added dropwise
3. waitto proceed at room temperature for 1 hour
4. extractionthe reaction solution was extracted with dichloromethane (50 ml*3)
5. dry with materialdried with anhydrous magnesium sulfate
6. filtrationfiltered
7. customto remove the drying agent
8. concentrationThe filtrate was concentrated under reduced pressure
9. customto give a solid
10. customThe solid was recrystallized in a 2:1 toluene/n-hexane mixture