反应详情

温度

70 °C

To a solution of 2,2,2-trichloroethyl 5-tert-butyl-3-(hydroxymethyl)-2-methoxyphenylcarbamate (0.096 g, 0.250 mmol) and 2-aminoindane (0.033 g, 0.248 mmol) in acetonitrile (1.0 mL), N,N-diisopropylethylamine (0.065 mL, 0.38 mmol) was added, and the mixture was stirred at 70° C. for 12 hours. The reaction mixture was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=0/100-60/40) to obtain 0.092 g (quantitative) of the captioned compound.

1. customThe reaction mixture was evaporated under reduced pressure
2. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=0/100-60/40)
3. customto obtain 0.092 g (quantitative) of the captioned compound