2-Chloro-4-(thiophen-2-yl)pyrimidine → 2-[(2-Thiophen-2-ylphenyl)carbonyl]-5-(4-thiophen-2-ylpyrimidin-2-yl)octahydro-pyrrolo[3,4-c]pyrrole

HRID 243924Notes

Reaction equation

HRID 243924 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)=[O:10].Cl[C:23]1[N:28]=[C:27]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[CH:26]=[CH:25][N:24]=1>>[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:9]([N:2]1[CH2:3][CH:4]2[CH:5]([CH2:6][N:7]([C:23]3[N:28]=[C:27]([C:29]4[S:30][CH:31]=[CH:32][CH:33]=4)[CH:26]=[CH:25][N:24]=3)[CH2:8]2)[CH2:1]1)=[O:10]

Participants

3

Reactant 2

HCID 141179412-Chloro-4-(thiophen-2-yl)pyrimidineHCID 67116155(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(2-thiophen-2-yl-phenyl)-methanone

Product 1

HCID 529170882-[(2-Thiophen-2-ylphenyl)carbonyl]-5-(4-thiophen-2-ylpyrimidin-2-yl)octahydro-pyrrolo[3,4-c]pyrrole

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 37 and 2-chloro-4-thiophen-2-yl-pyrimidine. MS (ESI) mass calcd. for C25H22N4OS2, 458.60; m/z found, 459.1 [M+H]+.

Sources & evidence

ORD record
ord-180551427c03412f9c35d9d0cb16b85c
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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