2-Chloro-6-fluorobenzothiazole → 6-Fluoro-2-{5-[(2-thiophen-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1,3-benzothiazole

HRID 243932Notes

Reaction equation

HRID 243932 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)=[O:10].Cl[C:23]1[S:24][C:25]2[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:26]=2[N:27]=1>>[F:32][C:30]1[CH:29]=[CH:28][C:26]2[N:27]=[C:23]([N:7]3[CH2:8][CH:4]4[CH:5]([CH2:1][N:2]([C:9]([C:11]5[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=5[C:17]5[S:18][CH:19]=[CH:20][CH:21]=5)=[O:10])[CH2:3]4)[CH2:6]3)[S:24][C:25]=2[CH:31]=1

Participants

3

Reactant 2

HCID 20498702-Chloro-6-fluorobenzothiazoleHCID 67116155(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(2-thiophen-2-yl-phenyl)-methanone

Product 1

HCID 529171636-Fluoro-2-{5-[(2-thiophen-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1,3-benzothiazole

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 37 and 2-chloro-6-fluoro-benzothiazole. MS (ESI) mass calcd. for C24H20FN3OS2, 449.57; m/z found, 450.0 [M+H]+.

Sources & evidence

ORD record
ord-e4b9309239a94462b4b5987409910dee
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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