HCID 67116252, compound → HCID 178519507, compound

HRID 243946Notes

Reaction equation

HRID 243946 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[C:18]([C:19]([F:22])([F:21])[F:20])=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[N:23]1[N:24]=[C:25]([C:28]2[CH:36]=[CH:35][CH:34]=[CH:33][C:29]=2[C:30](O)=[O:31])[NH:26][CH:27]=1>>[N:23]1[N:24]=[C:25]([C:28]2[CH:36]=[CH:35][CH:34]=[CH:33][C:29]=2[C:30]([N:7]2[CH2:6][CH:5]3[CH2:1][N:2]([C:9]4[C:18]([C:19]([F:22])([F:20])[F:21])=[N:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)[CH2:3][CH:4]3[CH2:8]2)=[O:31])[NH:26][CH:27]=1

Participants

3

Reactant 2

HCID 67116252HCID 67116252, compoundHCID 178524291HCID 178524291, compound

Product 1

HCID 178519507HCID 178519507, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 30 and 2-(4H-[1,2,4]triazol-3-yl)-benzoic acid. MS (ESI) mass calcd. for C24H20F4N7O, 479.47; m/z found, 480.2 [M+H]+. 1H NMR (CDCl3): 8.12-7.93 (m, 3H), 7.77 (dd, J=8.5, 0.9 Hz, 1H), 7.69 (ddd, J=8.4, 6.8, 1.4 Hz, 1H), 7.52-7.41 (m, 3H), 7.38-7.34 (m, 1H), 4.01-3.79 (m, 3H), 3.78-3.66 (m, 2H), 3.49 (dd, J=23.0, 15.0 Hz, 2H), 3.16-2.88 (m, 3H).

Sources & evidence

ORD record
ord-ff21b18afe4640afb3df9149f307117f
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

Loading…