2-Fluoro-6-(2-pyrimidinyl)benzoic acid → HCID 67116482, compound

HRID 243958Notes

Reaction equation

HRID 243958 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=1.[F:22][C:23]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[N:37]=[CH:36][CH:35]=[CH:34][N:33]=2)[C:24]=1[C:25](O)=[O:26]>>[F:22][C:23]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[N:33]=[CH:34][CH:35]=[CH:36][N:37]=2)[C:24]=1[C:25]([N:7]1[CH2:6][CH:5]2[CH2:1][N:2]([C:9]3[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=3)[CH2:3][CH:4]2[CH2:8]1)=[O:26]

Participants

3

Reactant 2

HCID 670866032-Fluoro-6-(2-pyrimidinyl)benzoic acidHCID 67116323[4-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-dimethyl-amine

Product 1

HCID 67116482HCID 67116482, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 36 and Intermediate 14. MS (ESI): mass calculated for C24H23F4N7O, 501.49; m/z found 502.0 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.86-8.63 (m, 2H), 8.22-8.05 (m, 1H), 7.56-7.40 (m, 1H), 7.29-7.18 (m, 1H), 7.12 (br s, 1H), 6.03-5.73 (m, 1H), 4.19-2.90 (m, 16H).

Sources & evidence

ORD record
ord-17d7ec8fee2d472990bfba87fb1b176c
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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