2-Chloro-4-methylpyrimidine → (2,4-Dimethoxy-phenyl)-[5-(4-methyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone

HRID 243992Notes

Reaction equation

HRID 243992 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]([N:13]1[CH2:20][CH:19]2[CH:15]([CH2:16][NH:17][CH2:18]2)[CH2:14]1)=[O:12].Cl[C:22]1[N:27]=[C:26]([CH3:28])[CH:25]=[CH:24][N:23]=1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]([N:13]1[CH2:20][CH:19]2[CH:15]([CH2:16][N:17]([C:22]3[N:27]=[C:26]([CH3:28])[CH:25]=[CH:24][N:23]=3)[CH2:18]2)[CH2:14]1)=[O:12]

Participants

3

Reactant 2

HCID 116296072-Chloro-4-methylpyrimidineHCID 66211208(2,4-Dimethoxy-phenyl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

Product 1

HCID 67116445(2,4-Dimethoxy-phenyl)-[5-(4-methyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 38 and 2-chloro-4-methylpyrimidine. MS (ESI): mass calculated for C20H24FN4O3, 368.43; m/z found 369.3 [M+H]+.

Sources & evidence

ORD record
ord-3e2e96135838425e9642176255af34ba
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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