2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 69939595, compound

HRID 244023Notes

Reaction equation

HRID 244023 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:18][CH:17]3[CH:13]([CH2:14][NH:15][CH2:16]3)[CH2:12]2)[N:4]=1.[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]([N:29]2[N:33]=[CH:32][CH:31]=[N:30]2)[C:21]=1[C:22](O)=[O:23]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:18][CH:17]3[CH2:16][N:15]([C:22]([C:21]4[C:25]([N:29]5[N:33]=[CH:32][CH:31]=[N:30]5)=[CH:26][CH:27]=[CH:28][C:20]=4[F:19])=[O:23])[CH2:14][CH:13]3[CH2:12]2)[N:4]=1

Participants

3

Reactant 2

HCID 670866272-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 671164912-(4,6-Dimethoxy-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

Product 1

HCID 69939595HCID 69939595, compound

Procedure

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 45 and Intermediate 12. MS (ESI): mass calculated for C21H22FN7O3, 439.18; m/z found 440.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.89-7.80 (m, 2H), 7.73 (s, 1H), 7.53-7.43 (m, 1H), 7.15 (tdd, J=8.4, 3.7, 0.9, 1H), 5.39 (d, J=2.4, 1H), 4.02-3.48 (m, 13H), 3.31-2.89 (m, 3H).

Sources & evidence

ORD record
ord-1476b5fe360d42bea3aa55b66ada544d
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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