反应详情

Intermediate 60 (100 mg, 0.252 mmol), DCM (2.5 mL), TFA (0.5 mL) were stirred at room temperature for 2 h and then concentrated in vacuo. The residue was dissolved in DCM and treated with Dowex 550 A resin. After stirring for 2 h the resin was removed by filtration and the filtrate was concentrated in vacuo to a colorless oil which was taken on to the next step without further purification. MS (ESI) mass calculated for C16H19N5O, 297.16; m/z found, 298.0.

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in DCM
3. additiontreated with Dowex 550 A resin
4. customwas removed by filtration
5. concentrationthe filtrate was concentrated in vacuo to a colorless oil which
6. customwas taken on to the next step without further purification