HCID 66841501, compound → HCID 66721005, compound

HRID 244065Notes

Reaction equation

HRID 244065 reaction equation
COC1C=C[C:6]([CH2:7][O:8][C:9]2[CH:10]=[C:11]([C:16]3[N:21]=[C:20]([C:22]([O:24][CH3:25])=[O:23])[CH:19]=[CH:18][C:17]=3[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[Cl:32])[CH:12]=[CH:13][C:14]=2[Cl:15])=[CH:5]C=1.Cl.ClC1C=CC([C:43]2[N:48]=[C:47](C(O)=O)C=CC=2C2C=CC=CC=2Cl)=CC=1OCCCN(C)C>>[Cl:15][C:14]1[CH:13]=[CH:12][C:11]([C:16]2[N:21]=[C:20]([C:22]([O:24][CH3:25])=[O:23])[CH:19]=[CH:18][C:17]=2[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[Cl:32])=[CH:10][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][N:48]([CH3:43])[CH3:47]

Participants

3

Reactant 2

HCID 66841501HCID 66841501, compoundHCID 66841537HCID 66841537, compound

Product 1

HCID 66721005HCID 66721005, compound

Procedure

According to the debenzylation/O-alkylation/saponification sequence described in Examples 1.7, 1.8 and 1.9, respectively, starting with 665 mg (1.35 mmol) of methyl 6-[3-[(4-methoxybenzyl)oxy]-4-chlorophenyl]-5-(2-chlorophenyl)pyridine-2-carboxylate, 181 mg of 6-{4-chloro-3-[3-(dimethylamino)propoxy]phenyl}-5-(2-chlorophenyl)pyridine-2-carboxylic acid hydrochloride are obtained in the form of a gum.

Workup

  1. customare obtained in the form of a gum

Sources & evidence

ORD record
ord-0cd618d66fe24a95b8ca5806d2e8df4b
Source dataset
uspto-grants-2014_02
Patent number
US08653276B2

Reaction notes

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