反应详情

温度

100 °C

The aforementioned compound 1, (500 mg, 1.56 mmol) and triethyl phosphite (1.07 mL, 6.24 mmol) was mixed and heated to 100° C. for 1 hr. The reaction mixture was subjected to N2 flow over weekend to remove the excess ethyl phosphite. The resulting yellow oil was purified on a 12 g silica gel column to yield a colorless oil (420 mg, 71% yield). 1H NMR (CD2Cl2) δ ppm: 7.72 (d, J=8.4 Hz, 2H), 7.54 (dd, J1=8.4 Hz, J2=2.4 Hz, 2H), 4.1-4.0 (m, 4H), 3.77-3.72 (m, 4H), 3.25 (d, J=22.4 Hz, 2H), 3.02-2.96 (m, 4H), 1.27 (t, J=7.2 Hz, 6H).

1. customto remove the excess ethyl phosphite
2. customThe resulting yellow oil was purified on a 12 g silica gel column