Potassium Carbonate → HCID 58241683, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-Methylphenyl boronic acid	HCID 2733267	—
Reactant	HCID 58241680	HCID 58241680	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Solvent	Dioxane acetonitrile water	HCID 67448433	—
Product	HCID 58241683	HCID 58241683	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

2-Iodo-1,3-dimethoxy-4-nitrobenzene (0.5 g, 1.62 mmol) was dissolved in dioxane/acetonitrile/water (10 ml/2 ml/2 ml), and 2-tolylboronic acid was added. Pd(dppf)Cl2 (0.11 mg, 0.16 mmol) and K2CO3 (0.33 g, 2.43 mmol) were added to this, and the mixture was stirred at 90° C. for 32 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2,6-dimethoxy-2′-methyl-3-nitrobiphenyl (0.2 g) as a colorless powder.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08658569B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-5b1b1be14d8a435994b14d920ea84ce1
Source note	uspto-grants-2014_02