反应详情

温度

90 °C

2-Iodo-1,3-dimethoxy-4-nitrobenzene (0.5 g, 1.62 mmol) was dissolved in dioxane/acetonitrile/water (10 ml/2 ml/2 ml), and 2-tolylboronic acid was added. Pd(dppf)Cl2 (0.11 mg, 0.16 mmol) and K2CO3 (0.33 g, 2.43 mmol) were added to this, and the mixture was stirred at 90° C. for 32 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2,6-dimethoxy-2′-methyl-3-nitrobiphenyl (0.2 g) as a colorless powder.

1. concentrationAfter concentration
2. customthe residue was chromatographed on silica gel