HCID 58241683, compound → HCID 58241679, compound

HRID 244328Notes

Reaction equation

HRID 244328 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[C:5]([O:12][CH3:13])[C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20]>CO.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[C:5]([O:12][CH3:13])[C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20]

Participants

4

Reactant 1

HCID 58241683HCID 58241683, compound

Product 1

HCID 58241679HCID 58241679, compoundYield 78.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

Pd/C (0.1 g) was added to 2,6-dimethoxy-2′-methyl-3-nitrobiphenyl (0.2 g, 0.73 mmol) in methanol (20 ml), and under 1 atm of Hz, the mixture was heated at 50° C. for 2 h. Filtration and concentration gave 2,6-dimethoxy-2′-methylbiphenyl-3-ylamine (0.14 g) as a colorless oil, which was directly reacted further.

Workup

  1. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-4da89c1414974d339722f7ecaa2d2e04
Source dataset
uspto-grants-2014_02
Patent number
US08658569B2

Reaction notes

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