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HRID244336

反应详情

EQUATION

反应方程式

HRID 244336 的结构方程式

REACTANTS

反应物

3
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：COc1c(Br)cc(C(C)(OC)OC)cc1C(C)(C)C
HCID23093719

1-Bromo-3-tert-butyl-5-(1,1-dimethoxyethyl)-2-methoxybenzene

C15H23BrO3

结构：CC(C)(C)[O-].[Na+]
HCID23676156

Sodium t-butoxide

C4H9NaO

PRODUCTS

生成物

1
结构：COc1c(N2CCOCC2)cc(C(C)(OC)OC)cc1C(C)(C)C
HCID23093724

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)[O-].CC(=O)[O-].[Pd+2]
催化剂HCID167845

Diacetatopalladium

C4H6O4Pd

结构：COCCOC
溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

Under a nitrogen atmosphere, 2-bromo-6-tert-butyl-4-(1,1-dimethoxyethyl)anisole (650 g, 1.962 mol), palladium acetate (4.4 g 19.6 mmol, 1 mol %) and (±)-BINAP (18.3 g, 29.4 mmol, 1.5 mol %) were dissolved in 1,2-dimethoxyethane (1.96 L) at room temperature. To the resultant solution, morpholine (205 g, 2.36 mol) and sodium tert-butoxide (264 g, 2.75 mol) were added.