反应详情

温度

90 °C

Potassium cyanide (2.0 g) was added to 15 ml of dimethylsulfoxide and heated to 90° C. 5-chloroethyl-2-oxindole (3.0 g) dissolved in 5 ml of dimethylsulfoxide was added slowly with stirring, and the reaction was heated to 150° C. and stirred for 2 hours. The mixture was cooled, poured into ice water and the precipitate which formed was collected by vacuum filtration, washed with water, and dried to give crude product. The crude material was chromatographed on silica gel (5% methanol in chloroform) to give 1.2 g (42%) of 5-cyanoethyl-2-oxindole.

1. additionwas added slowly
2. temperaturethe reaction was heated to 150° C.
3. stirringstirred for 2 hours
4. temperatureThe mixture was cooled
5. customthe precipitate which formed
6. filtrationwas collected by vacuum filtration
7. washwashed with water
8. customdried
9. customto give crude product
10. customThe crude material was chromatographed on silica gel (5% methanol in chloroform)