反应详情

温度

100 °C

To a solution of carbonyldiimidazole (0.282 mmol) in 1 mL pyridine was added ethylamine (0.282 mmol; 2.0 M in THF) dropwise. The mixture was stirred 5 hours and then 2,2,2-trifluoro-1-(1H-indazol-5-yl)-1-(1-methyl-1H-indol-3-yl)ethanol (0.189 mmol) was added. The mixture was heated at 100° C. for 16 hours in a sealed tube. Removal of the volatiles provided a residue which was purified by flash silica gel chromatography using 33% ethyl acetate in hexanes. The product-rich fractions were concentrated in vacuo to afford the title compound (0.045 mmol), m.p. 162° C.-164° C.

1. customRemoval of the volatiles
2. customprovided a residue which
3. customwas purified by flash silica gel chromatography
4. concentrationThe product-rich fractions were concentrated in vacuo