HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((Tert-butyldimethylsilyloxy)methyl)thiazole → 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-hydroxymethylthiazol-5-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((Tert-butyldimethylsilyloxy)methyl)thiazole | HCID 21480592 | — |
| Reactant | HCID 59437290 | HCID 59437290 | — |
| Product | 2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-hydroxymethylthiazol-5-yl)ethanol | HCID 68472581 | 17% |
Reaction Steps
The title compound (73.1 mg, 17% overall yield) was prepared from 2-(tert-butyldimethylsilanyloxymethyl)thiazole (242 mg, 1.06 mmol) according to methods described for the synthesis of 2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(2-hydroxymethyl-thiazol-4-yl)ethanol (Example 84). MS m/z 424.48 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658637B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-52ab04b64cab4bcea8f47db05a7a69cf |
| Source note | uspto-grants-2014_02 |