HCID 58579589, compound → HCID 58579582, compound

HRID 244510Notes

Reaction equation

HRID 244510 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 58579589HCID 58579589, compound2×

Product 1

HCID 58579582HCID 58579582, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of tert-butyl (4-nitrophenyl)(pyridin-2-ylmethyl)carbamate, 11a, (0.58 g, 1.76 mmol) in methanol (17 mL) was added Pd/C (50 mg) and an atmosphere of H2 was applied. After 14 h, the r×n was filtered through a plug of Celite and concentrated. The residue, 12a, was carried on without further purification.

Workup

  1. filtrationthe r×n was filtered through a plug of Celite
  2. concentrationconcentrated
  3. customThe residue, 12a, was carried on without further purification

Sources & evidence

ORD record
ord-81955ac9a9c9471da22b8cf800f32cf9
Source dataset
uspto-grants-2014_02
Patent number
US08658650B2

Reaction notes

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