Hydroxylamine → HCID 178480898, compound

HRID 244572Notes

Reaction equation

HRID 244572 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]#[N:10])[CH2:4][CH2:3]1.[NH2:11][OH:12]>C(O)C>[OH:12][NH:11][C:9](=[NH:10])[CH2:8][N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 10582860(4-methylpiperazin-1-yl)acetonitrile

Product 1

HCID 178480898HCID 178480898, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture (4-methylpiperazin-1-yl)acetonitrile (400 mg), hydroxylamine (50% aqueous solution, 2.0 mL) and ethanol (10.0 mL), was stirred at room temperature for 18 hours. The reaction mixture was evaporated to dryness to give a crystalline solid that was washed with hexane and dried under vacuum to give N-hydroxy-2-(4-methylpiperazin-1-yl)ethanimidamide (405 mg). 1H-NMR (400 MHz; CDCl3): 5.19 (br s, 3H), 3.00 (s, 2H), 2.75-2.28 (br m, 8H), 2.70 (s, 3H).

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customto give a crystalline solid
  3. washthat was washed with hexane
  4. customdried under vacuum

Sources & evidence

ORD record
ord-8e302a1a16c84dd5806015730c3698d9
Source dataset
uspto-grants-2014_02
Patent number
US08658654B2

Reaction notes

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