反应详情

Iron chips (2.4 g) were added in one portion to 4.6 g of 3′-ethoxy-3-nitrobiphenyl-4-acetic acid in glacial acetic acid (40 ml). The mixture was refluxed for 2 hours. The reaction mixture was cooled and concentrated to dryness. The residue was treated repeatedly with ethyl acetate and filtered to remove insolubles. The filtrate was washed twice with 1 N hydrochloric acid and brine, dried over anhydrous sodium sulfate and concentrated to give 3.5 g (91%) of 6-(3-ethoxyphenyl)-2-oxindole as a light brown solid.

1. temperatureThe mixture was refluxed for 2 hours
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated to dryness
4. additionThe residue was treated repeatedly with ethyl acetate
5. filtrationfiltered
6. customto remove insolubles
7. washThe filtrate was washed twice with 1 N hydrochloric acid and brine
8. dry with materialdried over anhydrous sodium sulfate
9. concentrationconcentrated