Hydrochloric Acid → HCID 19619902, compound

HRID 244621Notes

Reaction equation

HRID 244621 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH:11]([CH3:13])[CH3:12])[C:6]=1[C:7]([O:9]C)=[O:8].Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH:11]([CH3:13])[CH3:12])[C:6]=1[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58356372HCID 58356372, compound

Product 1

HCID 19619902HCID 19619902, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
105 °C

Procedure

A solution of methyl 4-chloro-1-(1-methylethyl)-1H-pyrazole-5-carboxylate (130 mg) in 1,4-dioxane (3 ml) was treated with 2M hydrochloric acid (3 ml) and the mixture heated at 105° C. for 90 h. The mixture was evaporated in vacuo to give the title compound as a white solid (120 mg).

Workup

  1. customThe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-86a342d858d4437aa928abf17f1d7ad3
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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