反应详情

Ethyl 2-methyl-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (200 mg) was dissolved in 1,4-dioxane (2 ml). Hydrochloric acid (2 ml) was added and the mixture was heated at reflux under nitrogen for 18 h. One drop of concentrated hydrochloric acid was added and the mixture was heated at reflux for 72 h. The mixture was cooled to RT, the solvent was removed in vacuo and toluene (15 ml) was added. The solvent was removed in vacuo to give a brown oil which solidified on standing. The product was dried in a vacuum oven overnight to give the title compound (171 mg) as a brown solid.

1. temperaturethe mixture was heated
2. temperatureat reflux under nitrogen for 18 h
3. temperaturethe mixture was heated
4. temperatureat reflux for 72 h
5. customthe solvent was removed in vacuo and toluene (15 ml)
6. additionwas added
7. customThe solvent was removed in vacuo
8. customto give a brown oil which
9. customThe product was dried in a vacuum oven overnight