反应详情

Iron chips (2.6 g) were added all at once to 4.5 g of 3-nitrobiphenyl-4-acetic acid in 40 ml of acetic acid. The mixture was refluxed for 2 hours, concentrated to dryness and the residue taken up in ethyl acetate. The solids were removed by filtration and the filtrate washed twice with 1 N hydrochloric acid and brine and dried over anhydrous sodium sulfate. The filtrate was concentrated to give 3.4 g (93% yield) of 6-phenyl-2-oxindole as a light brown solid.

1. temperatureThe mixture was refluxed for 2 hours
2. concentrationconcentrated to dryness
3. customThe solids were removed by filtration
4. washthe filtrate washed twice with 1 N hydrochloric acid and brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationThe filtrate was concentrated