反应详情

温度

-78 °C

1-(1-Methylethyl)-1H-1,2,4-triazole (1 g) was dissolved in THF (15 ml) and cooled to −78° C. under nitrogen. A 1.6 M solution of butyllithium in hexane (5.9 ml) was added dropwise. The solution was stirred for 1.5 h at −78° C., then the solution was treated with solid carbon dioxide (2 g). After 30 min at −78° C. the solution was allowed to warm to RT and stirred overnight. The reaction was quenched with water (1 ml), concentrated in vacuo and dried in a vacuum oven for 1 day at 50° C. to give the title compound (1.29 g) as a white solid.

1. waitAfter 30 min at −78° C. the solution was allowed
2. temperatureto warm to RT
3. stirringstirred overnight
4. customThe reaction was quenched with water (1 ml)
5. concentrationconcentrated in vacuo
6. customdried in a vacuum oven for 1 day at 50° C.