反应详情

温度

20 °C

To a stirred solution of 2-cyclopropyl-1H-pyrrolo[2,3-b]pyridine (7.6 g) in DME (100 ml) was added a solution of m-chloroperoxybenzoic acid (17.9 g) in DME (50 ml), under an atmosphere of nitrogen, keeping the temperature between 20 and 25° C. The resulting suspension was stirred at 20° C. for 45 min and then sodium metabisulphite solution (20 ml, 40%) was added. The mixture was concentrated in vacuo to ˜80 ml. Water (100 ml) was added and the mixture basified by the addition of aqueous potassium carbonate solution. The suspension was stirred for 14 h and then the precipitate was collected by filtration, washed with water and dried to give the title compound (4.1 g).

1. customthe temperature between 20 and 25° C
2. concentrationThe mixture was concentrated in vacuo to ˜80 ml
3. additionWater (100 ml) was added
4. additionthe mixture basified by the addition of aqueous potassium carbonate solution
5. stirringThe suspension was stirred for 14 h
6. filtrationthe precipitate was collected by filtration
7. washwashed with water
8. customdried