HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 244662Generated: October 25, 2026
Hydrochloric Acid → 2-Amino-5-isopropylthiazole-4-carboxylic acid
https://huagongshe.com/reaction/244662
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-amino-5-(propan-2-yl)-1,3-thiazole-4-carboxylate | HCID 737584 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-5-isopropylthiazole-4-carboxylic acid | HCID 10058249 | 117.3% |
Reaction Steps
To a solution of methyl 2-amino-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (220 mg) (for example, available from ABCR) in 1,4-dioxane (5 ml) was added 2M hydrochloric acid (5 ml) and the mixture heated at 110° C. for 72 h. The mixture was evaporated in vacuo to give the title compound (240 mg) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08658635B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-75d90a6cef4a4fc39f866710bd04e50c |
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| Source note | uspto-grants-2014_02 |
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